Around 25 other individuals were harmed in the fire at the Virgen de Asuncion shield in San Jose Pinula, around 25km (15 miles) south-east of the capital, Guatemala City.
Police said the blast may have been begun by a portion of the inhabitants.
On Tuesday, cops mediated after a mob broke out at the home. Around 60 youngsters got away.
Some affirmed they had been abused or sexually manhandled.
Oscar Franco, a representative for the volunteer firefighters, told nearby media: “No less than 25 individuals were harmed and exchanged to healing centers and we have affirmed 19 bodies.”
The fire tore through the office in minutes.
Nery Ramos, the leader of Guatemala’s national police, said the fire was begun by a gathering of youngsters at the safe house.
Firefighters combat to contain the flares as frantic relatives landed at the scene to attempt to locate their friends and family.
After the burst, pictures demonstrated blazed bodies canvassed by covers lying in one of the darkened rooms.
The kids who fled on the eve of the fire said it was because of poor conditions and abuse taking after the uproar, which left the office harmed.
The UN kids’ reserve in Guatemala said on Twitter it “censures the catastrophe at the Virgin of the Assumption Home. These kids and teenagers must be secured.”
Neighborhood reports say the limit of the house is 400, however that numerous more youngsters were living there at the time.
The haven takes in kids up to the age of 18 who have endured mishandle or trafficking, or have been relinquished.
In any case, neighborhood media say the sanctuary was additionally working as an adolescent confinement focus, to which judges were sending young people required in criminal cases.